How to Grow Psilocybin Mushrooms

Psilocybes are conditionally toxic mushrooms that have hallucinogenic properties due to the high content of psilocin and psilocybin alkaloids. The most potent varieties of psilocybin mushrooms grow in India, Indonesia, Mexico, and South America, but magic mushrooms can also be purchased online at or cultivated at home.

Preparation of tools and materials

To get a generous harvest, you need to prepare a whole arsenal of devices, and for the first and second stages of cultivation you will need your own set.

First, make sure to buy high quality psilocybin mushroom spores, which will give a great harvest. For ease of use and uniform distribution over the base, the biomaterial is placed in a medical syringe.

Decide in advance on the place where the mushroom colony will be located. It must be protected from prying eyes, drafts and direct sunlight. The ideal location would be a cellar or basement.

First stage of growing

The initial phase is aimed at creating a “cake” – the basis for the cultivation of psilocybin mushrooms. Once the mycelium colonizes the entire inoculation jar and becomes attached to the substrate, it can be removed from the jar.

Step #1: Disinfection

The greatest danger to fungal spores are pathogenic bacteria that can enter the container during inoculation. The grow box creates an ideal environment for the growth and reproduction of pathogenic microflora, which ultimately infects the spores of psilocybin mushrooms. To prevent infection, the grower must carefully follow the rules of disinfection, use antiseptics and protective equipment.

Stage #2: Grafting

  • While holding the needle in your hand, shake the biomaterial syringe to distribute the spores evenly.
  • Insert the sterilized needle into the syringe port and inject the culture into the prepared container.

Stage #3: Sprouting

After distributing the culture into jars, place the vessels in a previously prepared container and leave in a warm, dark place. Watch the temperature – it should be kept in the range from +26 °С to +30 °С. Do not open the box and do not move the jars for 5 days – during this time the mycelium is formed.

If after 5 days a white substance appears in the vessels, then the work was done correctly. Leave the mycelium to develop for another week, then move on to the next growing stage.

Second stage of growing

The task of this stage is to carefully remove the colonized substrate from the jar and wait for the germination of full-fledged psilocybin mushrooms.


Carefully separate the ripened psilocybin mushrooms from the mycelium and place in an airtight container. Store the harvested crop in a cool place.

One “cake” usually produces a good harvest, so there is no need to use more than 10 jars for one grove. This amount is enough to evenly distribute all the psilocybin mushroom spores from one syringe and get a large amount of grow.

Can psilocybes be grown outdoors?

Not all mushroom strains are suitable for outdoor cultivation, but if you can get a suitable strain, you can try growing psilocybe outdoors. The main difficulties of outdoor cultivation are the increased risks of infection. Therefore, most of the grower’s efforts should be aimed at creating conditions for maximum sterility.

Jeff Campbell